The PLACER PFA seeks to fund high-quality, comparative clinical effectiveness research (CER) projects that will address critical decisional choices faced by patients, caregivers, clinicians, and stakeholders across the health and healthcare community. Investigators should propose an individual-level or cluster randomized controlled trial of significant scale and scope for this PFA. The proposed trials should address critical decisional dilemmas that require important new evidence about the comparative clinical effectiveness of available interventions. Proposed studies should compare interventions that already have established evidence of efficacy or are in widespread use. Clinical interventions (such as medications, diagnostic tests, or procedures) and delivery system interventions are appropriate for these studies.

Please review the full funding announcement on the PCORI website for more information about this PFA and register for the town hall on September 12, 2022, from 11:30 am – 1 pm (ET). Those interested in applying can also email sciencequestions@pcori.org with questions or speak with a PCORI Program Officer. Letters of Intent, the first step in our application process, are due October 4 for this PFA.